TRI Academy Online Seminar Series - Episode # 2: Tinnitus Mechanisms

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The Tinnitus Research Initiative Foundation brings you TRIAcademy's Episode #2 in its monthly Online Seminar Series

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In the second episode of TRI Academy's Online Seminar Series, the following speakers will be presenting:

Sven Vanneste, Ireland: "What is buzzing? The systems neuroscience of tinnitus"

Recent findings support the hypothesis that the perception of tinnitus is associated with the activation of a central neural network with multiple inputs and outputs, including auditory, perceptual, affective, and attention components. In this presentation I will focus on the main principles underlying tinnitus and its mechanisms. The major neurophysiological tinnitus models including the deafferentation model and the noise-cancelling mode will be discussed as well as the integration of these models into global triple network model that generalize these approaches.

Arnaud Noreña, France: "Changes in the spatio-temporal pattern of spontaneous activity in the auditory cortex of guinea pig after noise-induced hearing loss"

It is well-known that tinnitus can be induced in humans after noise trauma. Hereby, this treatment is often used in animal studies to reveal the neural changes triggered after noise-induced hearing loss that are potentially linked to tinnitus. The present study is aimed at investigating the changes in the spatio-temporal pattern of spontaneous activity in the auditory cortex of guinea pig after noise-induced hearing loss. More specifically, we recorded local field potentials and multi-unit activity over an entire cortical column using a alinear array of micro-electodes before and after noise trauma. The current source density was calculated to estimate the cortical current sinks. Our results suggest that noise trauma changes dramatically the propagation of cortical activity. In particular, the propagation of activity is much enhanced after noise trauma. These cortical changes may play a role in the mechanisms of tinnitus.

The session will be moderated by Anusha Mohan, Trinity College Dublin, Ireland.

After welcoming remarks, each session will include two 20-minute talks. Questions from the audience for both talks will be moderated towards the end of the session.

A Zoom invitation link for this seminar will be provided in ample time before the event date.

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Organiser TRI - Tinnitus Research Initiative Foundation

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